Detection of viral DNA in kidney graft preservation and washing solutions is predictive of posttransplant infections in pediatric recipients
Journal of Infectious Diseases, ISSN: 0022-1899, Vol: 200, Issue: 9, Page: 1425-1433
2009
- 18Citations
- 36Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef6
- Captures36
- Readers36
- 36
Article Description
Background: In pediatric kidney transplant recipients, viral infections occur soon after transplant and may be transmitted from the graft. Methods: This study of 75 pediatric kidney transplants investigated whether genome sequences of parvovirus B19, Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), and BK polyomavirus (BKV) could be detected in kidney graft samples (graft biopsy samples and preservation and washing solutions) collected before implantation and whether their presence was a risk factor for infections in the recipient. Results: B19 DNA was detected in ∼30% of graft biopsy samples, preservation solutions, and washing solutions; EBV DNA was detected in ∼20% of preservation and washing solutions but rarely in biopsy samples; and HCMV DNA and BKV DNA were rarely detected in graft biopsy samples. Seronegative recipients of B19 DNA-positive and EBV DNA-positive grafts had a significantly higher risk of infection during the early posttransplant period than did recipients of negative grafts. In particular, none of the B19-seronegative recipients of B19 DNA-negative grafts experienced infection soon after transplant, whereas most recipients of B19 DNA-positive grafts experienced infection within the first month after transplant. Conclusions: Molecular testing of donor grafts for viruses that infect circulating and resident cells in the graft- such as B19 in the kidney-could be useful (in association with donor/recipient serostatus) for identifying recipients at high risk for posttransplant infections. © 2009 by the Infectious Diseases Society of America.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=72849125459&origin=inward; http://dx.doi.org/10.1086/644504; http://www.ncbi.nlm.nih.gov/pubmed/19803803; https://academic.oup.com/jid/article-lookup/doi/10.1086/644504; https://dx.doi.org/10.1086/644504; https://academic.oup.com/jid/article-abstract/200/9/1425/851669?redirectedFrom=fulltext
Oxford University Press (OUP)
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