PlumX Metrics
Embed PlumX Metrics

Detection of viral DNA in kidney graft preservation and washing solutions is predictive of posttransplant infections in pediatric recipients

Journal of Infectious Diseases, ISSN: 0022-1899, Vol: 200, Issue: 9, Page: 1425-1433
2009
  • 18
    Citations
  • 0
    Usage
  • 36
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Background: In pediatric kidney transplant recipients, viral infections occur soon after transplant and may be transmitted from the graft. Methods: This study of 75 pediatric kidney transplants investigated whether genome sequences of parvovirus B19, Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), and BK polyomavirus (BKV) could be detected in kidney graft samples (graft biopsy samples and preservation and washing solutions) collected before implantation and whether their presence was a risk factor for infections in the recipient. Results: B19 DNA was detected in ∼30% of graft biopsy samples, preservation solutions, and washing solutions; EBV DNA was detected in ∼20% of preservation and washing solutions but rarely in biopsy samples; and HCMV DNA and BKV DNA were rarely detected in graft biopsy samples. Seronegative recipients of B19 DNA-positive and EBV DNA-positive grafts had a significantly higher risk of infection during the early posttransplant period than did recipients of negative grafts. In particular, none of the B19-seronegative recipients of B19 DNA-negative grafts experienced infection soon after transplant, whereas most recipients of B19 DNA-positive grafts experienced infection within the first month after transplant. Conclusions: Molecular testing of donor grafts for viruses that infect circulating and resident cells in the graft- such as B19 in the kidney-could be useful (in association with donor/recipient serostatus) for identifying recipients at high risk for posttransplant infections. © 2009 by the Infectious Diseases Society of America.

Bibliographic Details

Barzon, Luisa; Murer, Luisa; Pacenti, Monia; Biasolo, Maria Angela; Vella, Manuela Della; Ghirardo, Giulia; Gamba, Pier Giorgio; De Arias, Alejandro Espadas; Zanon, Giovanni Franco; Palù, Giorgio

Oxford University Press (OUP)

Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know