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Drug loaded magnetic nanoparticles for cancer therapy

Journal of Physics Condensed Matter, ISSN: 0953-8984, Vol: 18, Issue: 38, Page: S2893-S2902
2006
  • 269
    Citations
  • 0
    Usage
  • 253
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    269
    • Citation Indexes
      266
    • Patent Family Citations
      2
      • Patent Families
        2
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    253

Article Description

Magnetic nanoparticles have been investigated for biomedical applications for more than 30years. In medicine they are used for several approaches such as magnetic cell separation or magnetic resonance imaging (MRI). The development of biocompatible nanosized drug delivery systems for specific targeting of therapeutics is the focus of medical research, especially for the treatment of cancer and diseases of the vascular system. In an experimental cancer model, we performed targeted drug delivery and used magnetic iron oxide nanoparticles, bound to a chemotherapeutic agent, which were attracted to an experimental tumour in rabbits by an external magnetic field (magnetic drug targeting). Complete tumour remission could be achieved. An important advantage of these carriers is the possibility for detecting these nanoparticles after treatment with common imaging techniques (i.e.x-ray-tomography, magnetorelaxometry, magnetic resonance imaging), which can be correlated to histology. © 2006 IOP Publishing Ltd.

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