Drug loaded magnetic nanoparticles for cancer therapy
Journal of Physics Condensed Matter, ISSN: 0953-8984, Vol: 18, Issue: 38, Page: S2893-S2902
2006
- 269Citations
- 253Captures
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Article Description
Magnetic nanoparticles have been investigated for biomedical applications for more than 30years. In medicine they are used for several approaches such as magnetic cell separation or magnetic resonance imaging (MRI). The development of biocompatible nanosized drug delivery systems for specific targeting of therapeutics is the focus of medical research, especially for the treatment of cancer and diseases of the vascular system. In an experimental cancer model, we performed targeted drug delivery and used magnetic iron oxide nanoparticles, bound to a chemotherapeutic agent, which were attracted to an experimental tumour in rabbits by an external magnetic field (magnetic drug targeting). Complete tumour remission could be achieved. An important advantage of these carriers is the possibility for detecting these nanoparticles after treatment with common imaging techniques (i.e.x-ray-tomography, magnetorelaxometry, magnetic resonance imaging), which can be correlated to histology. © 2006 IOP Publishing Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33749533577&origin=inward; http://dx.doi.org/10.1088/0953-8984/18/38/s24; http://stacks.iop.org/0953-8984/18/i=38/a=S24?key=crossref.b0e659c842bbddf5cd9c37c9a8a367ee; https://iopscience.iop.org/article/10.1088/0953-8984/18/38/S24; http://stacks.iop.org/0953-8984/18/i=38/a=S24/pdf; https://dx.doi.org/10.1088/0953-8984/18/38/s24; https://validate.perfdrive.com/fb803c746e9148689b3984a31fccd902/?ssa=39edbf38-dd14-40bc-ba0b-07e2cf9860dc&ssb=65943230337&ssc=https%3A%2F%2Fiopscience.iop.org%2Farticle%2F10.1088%2F0953-8984%2F18%2F38%2FS24&ssi=657b1ea2-8427-4988-9373-173ec08ecf6b&ssk=support@shieldsquare.com&ssm=1084603961467802883320217229544514&ssn=6908abf6da936ecd0b01e5af1681c8100707c2ae0ce4-ff45-4181-b09a1a&sso=2ecd50ab-6a09cacfa10d070a70f5dc17d43ec223ee8c0ae4adc2d573&ssp=26250263491717606911171771667918323&ssq=99642509985864969050810240381015268046767&ssr=NTIuMy4yMTcuMjU0&sst=com.plumanalytics&ssu=&ssv=&ssw=&ssx=eyJyZCI6ImlvcC5vcmciLCJ1em14IjoiN2Y5MDAwNDE4ZWY3ODAtNTQ0OS00ODIyLThiYTYtMzY2YzgzNTMxOWY3My0xNzE3NjEwMjQwNDE1MTg5NjE3NzU3LWE0OGQ4ZjRiNGFhODE0YTU4MzMyIiwiX191em1mIjoiN2Y2MDAwNjEzZjZhMzItZjViOS00NWMxLThlMGYtOGNiNmIxOGYzNzVkMTcxNzYxMDI0MDQxNTE4OTYxNzc1Ny1mOWRiNzM1ZDQzNjhhZmIzODMzMiJ9
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