Enhanced intratumoral uptake of quantum dots concealed within hydrogel nanoparticles
Nanotechnology, ISSN: 0957-4484, Vol: 19, Issue: 48, Page: 485102
2008
- 22Citations
- 28Captures
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef19
- Captures28
- Readers28
- 28
Article Description
Effective nanomedical devices for tumor imaging and drug delivery are not yet available. In an attempt to construct a more functional device for tumor imaging, we have embedded quantum dots (which have poor circulatory behavior) within hydrogel nanoparticles made of poly-N-isopropylacrylamide. We found that the hydrogel encapsulated quantum dots are more readily taken up by cultured tumor cells. Furthermore, in a melanoma model, hydrogel encapsulated quantum dots also preferentially accumulate in the tumor tissue compared with normal tissue and have ∼16-fold greater intratumoral uptake compared to non-derivatized quantum dots. Our results suggest that these derivatized quantum dots, which have greatly improved tumor localization, may enhance cancer monitoring and chemotherapy. © IOP Publishing Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=58149265168&origin=inward; http://dx.doi.org/10.1088/0957-4484/19/48/485102; http://www.ncbi.nlm.nih.gov/pubmed/21836292; https://iopscience.iop.org/article/10.1088/0957-4484/19/48/485102; https://dx.doi.org/10.1088/0957-4484/19/48/485102; https://validate.perfdrive.com/9730847aceed30627ebd520e46ee70b2/?ssa=cf951044-f5e8-4284-b063-17be61174944&ssb=79666241247&ssc=https%3A%2F%2Fiopscience.iop.org%2Farticle%2F10.1088%2F0957-4484%2F19%2F48%2F485102&ssi=bb2c758a-cnvj-4905-8085-0e24bfae771a&ssk=botmanager_support@radware.com&ssm=374092617787486094996081266251444&ssn=aa618688c0915ca25405f2a960e04ad0a7756e9c6c62-bdb9-4deb-8dd11f&sso=002b3081-d7b4100be1c4f522f7ee44112bbd8df50f8b3a38f3caaff9&ssp=00299893661729758325172977120331749&ssq=48099411154109699204506969115170796097623&ssr=NTIuMy4yMTcuMjU0&sst=com.plumanalytics&ssu=&ssv=&ssw=&ssx=eyJ1em14IjoiN2Y5MDAwZjE4MDUxZmYtNjRmOS00MmIyLWI5NTAtOTA0ZDU2OWUyZWUyMS0xNzI5NzA2OTY5NTIzNDU3MjI1OS05ZTFjZmQ0YTM0NWMxYWRhNDk5IiwicmQiOiJpb3Aub3JnIiwiX191em1mIjoiN2Y2MDAwZTVhNzFiZGQtNDYxNy00NWY1LTkyOTgtMjRlZGNmOTA4N2EwMTcyOTcwNjk2OTUyMzQ1NzIyNTktOGNhZjdiZTg1YjllNGJhMTQ5OSJ9
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