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Investigation of Antimicrobial activity of CTAB assisted hydrothermally derived Nano BaTiO

Materials Research Express, ISSN: 2053-1591, Vol: 6, Issue: 2
2019
  • 13
    Citations
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  • 16
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    13
    • Citation Indexes
      13
  • Captures
    16

Article Description

In spite of demonstrated application of nano barium titanate (BaTiO) in biomedical applications, its antibacterial/fungal activity and biocompatibility studies are hitherto unexplored. Present work reports synthesis, characterization and assessment of antimicrobial and hemolytic activity of nano BaTiO, owing to their potential futuristic biomedical applications. Nano BaTiO is prepared by surfactant (Hexadecyltrimethylammonium bromide, CTAB) assisted hydrothermal synthesis and is characterized by various analytical and spectroscopic techniques. Morphology of the as synthesized nano BaTiO is cubic in nature. Based on the characterization techniques, nano BaTiO synthesised using 15 mM CTAB (15-CBT) were considered for antimicrobial activity against various multidrug-resistant pathogens. Good inhibition activity was observed against C. albicans with MIC value of 0.37 mg ml and MFC of 0.75 mg ml. C. albicans treated with 10 mg of 15-CBT showed only 30% cell viability. The anticandidal mechanism of nano BaTiO against C. albicans was attributed to decrease in ergosterol biosynthesis leading to cell death. Further, only 3% hemolytic activity on human blood RBCs was observed at 0.2 mg ml of 15-CBT. The anticandidal activity and hemolytic activity of the synthesised nano BaTiO is systematically investigated and reported.

Bibliographic Details

M. Sasikumar; N. Ananth; A. Ganeshkumar; R. Rajaram; M. N. Chandraprabha; R. Hari Krishna; P. Sivakumar

IOP Publishing

Materials Science

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