Sequence of a Placental cDNA Encoding the Mouse Insulin-Like Growth Factor II Precursor
DNA, ISSN: 1557-7430, Vol: 5, Issue: 5, Page: 357-361
1986
- 67Citations
- 5Captures
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Metrics Details
- Citations67
- Citation Indexes67
- 67
- CrossRef51
- Captures5
- Readers5
Article Description
cDNAs encoding the mouse insulin-like growth factor II (IGF-II) precursor have been isolated from a placental library and sequenced. Mouse prepro-IGF-II is predicted to be 180 amino acids and has 84% and 97% identity with human and rat IGF-II precursors, respectively. There are two prepro-IGF-II transcripts in mouse placenta; the major transcript is 3850 bases and the minor one is 4800 bases. Prepro-IGF-II mRNA cannot be detected in adult mouse liver, but it is readily detected in adult human liver, indicating that there are differences in the regulation of expression of the IGF-II gene in the liver of adult mice and human beings. © 1986, Mary Ann Liebert, Inc. All rights reserved.
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