Identification of a Gene Family Regulated by Transforming Growth Factor-β
DNA and Cell Biology, ISSN: 1557-7430, Vol: 10, Issue: 4, Page: 293-300
1991
- 120Citations
- 15Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations120
- Citation Indexes120
- 120
- CrossRef101
- Captures15
- Readers15
- 15
Article Description
We have identified two related genes whose mRNAs are increased after treatment with transforming growth factor-β (TGF-β1). Mouse AKR-2B cells were treated with TGF-β1 in the presence of cyclohexamide and a cDNA library was subjected to differential screening. Several TGF-β-induced genes (βIG) were isolated and two of these, βIG-M1 and βIG-M2, were characterized. βIG-M1 and βIG-M2 RNAs were significantly increased after TGF-β1 treatment and both were superinduced in the presence of cyclohexamide. cDNA sequence analysis of βIG-M1 showed that it encoded a 379-amino-acid protein which was 81% homologous to CEF-10, a v-src and TPA-inducible gene, and identical to cyr61, a gene induced by serum in growth-arrested BALB-3T3 cells. cDNA sequence analysis of βIG-M2 showed that it encoded a 348-amino-acid protein that was 50% homologous to βIG-M1. Thirty-eight cysteine residues are conserved between βIG-M1 and βIG-M2, which are clustered at the amino and carboxy ends: The middle regions of the two proteins are cysteine free and display the highest degree of nonhomology. Both proteins contain an amino-terminal cysteine-rich motif common to insulin-like growth factor binding proteins and a carboxy-terminal domain with strong homology to a motif found near the carboxy-terminal of the malarial circumsporozoite protein which may be involved in cell adhesion. The regulation of mRNA encoding these proteins by TGF-β1 suggests that they may be involved in mediating some of the pleiotropic effects of this multipotent modulator of cell growth and differentiation. © 1991, Mary Ann Liebert, Inc. All rights reserved.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know