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Dynamics of DNA methylation in aging and Alzheimer's disease

DNA and Cell Biology, ISSN: 1044-5498, Vol: 31, Issue: SUPPL. 1, Page: S42-8
2012
  • 71
    Citations
  • 0
    Usage
  • 150
    Captures
  • 0
    Mentions
  • 6
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    71
  • Captures
    150
  • Social Media
    6
    • Shares, Likes & Comments
      6
      • Facebook
        6

Review Description

Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to be essential components of epigenetic regulation in the mammalian central nervous system. In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease. © 2012 Mary Ann Liebert, Inc.

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