LncRNA MIR4435-2HG is a potential early diagnostic marker for ovarian carcinoma
Acta Biochimica et Biophysica Sinica, ISSN: 1745-7270, Vol: 51, Issue: 9, Page: 953-959
2019
- 19Citations
- 11Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef14
- Captures11
- Readers11
- 11
Article Description
LncRNA MIR4435-2HG is characterized as an oncogene in lung cancer. However, its role in ovarian carcinoma (OC) is unclear. In this study, we aimed to investigate the role of MIR4435-2HG in OC. We found that both MIR4435-2HG and transforming growth factor beta 1 (TGF-β1) were upregulated in OC. MIR4435-2HG is associated with tumor metastasis but not with tumor size. Upregulation of MIR4435-2HG distinguished early stage (Stage I and II) OC patients from healthy controls. Correlation analysis showed that plasma levels of MIR4435-2HG and TGF-β1 were positively correlated only in OC patients. qPCR and western blot analysis results showed that MIR4435-2HG overexpression led to upregulation of TGF-β1 in OC cells, while TGF-β1 treatment did not significantly affect MIR4435-2HG expression. Transwell invasion and migration assays showed that MIR4435-2HG and TGF-β1 promoted the invasion and migration of OC cells while TGF-β inhibitor suppressed the invasion and migration of these cells. Further analysis of the Transwell invasion and migration assay results showed that TGF-β inhibitor reduced the effects of MIR4435-2HG overexpression. Therefore, our results suggested that lncRNA MIR4435-2HG may promote OC by upregulating TGF-β1. Further characterization of the functions of MIR4435-2HG in OC may provide novel targets for cancer therapies.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85071996323&origin=inward; http://dx.doi.org/10.1093/abbs/gmz085; http://www.ncbi.nlm.nih.gov/pubmed/31435668; http://engine.scichina.com/doi/10.1093/abbs/gmz085; https://dx.doi.org/10.1093/abbs/gmz085; https://academic.oup.com/abbs/article/51/9/953/5552402; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=6649893&internal_id=6649893&from=elsevier
China Science Publishing & Media Ltd.
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