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Associations of fat and muscle tissue with cognitive status in older adults: The AGES-Reykjavik Study

Age and Ageing, ISSN: 1468-2834, Vol: 46, Issue: 2, Page: 250-257
2017
  • 42
    Citations
  • 0
    Usage
  • 91
    Captures
  • 1
    Mentions
  • 58
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    42
  • Captures
    91
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    58
    • Shares, Likes & Comments
      58
      • Facebook
        58

Most Recent News

Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.

Age Ageing. 2017 Mar 1;46(2):250-257. Authors: Spauwen PJ, Murphy RA, Jónsson PV, Sigurdsson S, Garcia ME, Eiriksdottir G, van Boxtel MP, Lopez OL, Gudnason V, Harris TB, Launer LJ PubMed: 28399220 Submit Comment

Article Description

Background/Objective: studies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life. Methods: we studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykjavik Study of whom 485 (9.4%) were diagnosed with mild cognitive impairment (MCI) and 307 (5.9%) with dementia. Visceral fat, abdominal and thigh subcutaneous fat, and thigh muscle were assessed by computed tomography. MCI and dementia were based on clinical assessment and a consensus meeting; those without MCI or dementia were categorised as normal. Multinomial regression models assessed the associations stratified by sex and in additional analyses by midlife body mass index (BMI). Results: among women, there was a decreased likelihood of dementia per SD increase in abdominal subcutaneous fat (OR 0.72; 95% CI: 0.59-0.88), thigh subcutaneous fat (0.81; 0.67-0.98) and thigh muscle (0.63; 0.52-0.76), but not visceral fat, adjusting for demographics, vascular risk factors, stroke and depression. Inverse associations of fat with dementia were attenuated by weight change from midlife and were strongest in women with midlife BMI < 25. In men, one SD increase in thigh muscle was associated with a decreased likelihood of dementia (0.75; 0.61-0.92). BC was not associated with MCI in men or women. Conclusion: a higher amount of abdominal and thigh subcutaneous fat were associated with a lower likelihood of dementia in women only, while more thigh muscle was associated with a lower likelihood of dementia in men and women.

Bibliographic Details

Spauwen, Peggy J J; Murphy, Rachel A; Jónsson, Pálmi V; Sigurdsson, Sigurdur; Garcia, Melissa E; Eiriksdottir, Gudny; van Boxtel, Martin P J; Lopez, Oscar L; Gudnason, Vilmundur; Harris, Tamara B; Launer, Lenore J

Oxford University Press (OUP)

Biochemistry, Genetics and Molecular Biology; Medicine

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