Menstrual cycle effects on the metabolism of tryptophan loads
The American Journal of Clinical Nutrition, ISSN: 0002-9165, Vol: 50, Issue: 1, Page: 46-52
1989
- 36Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef23
- Captures17
- Readers17
- 17
Article Description
The metabolism of tryptophan (Trp) was examined during the follicular and luteal phases of the human menstrual cycle. Eight healthy women were administered capsulated Trp (3 g) or placebo (3 g lactose) during two follicular and two luteal phases of their menstrual cycles. Trp loading resulted in increased plasma concentrations of Trp and kynurenine, in an increase in the ratio of Trp to neutral amino acids in plasma, and in an increase in urinary excretion of Trp and kynurenine at both phases of the menstrual cycle. However at 3 h after Trp ingestion, plasma kynurenine levels in the luteal phase (23.6 +/- 3.1 mumol/L) were 40% higher than in the follicular phase (16.7 +/- 1.1 mumol/L) (p less than 0.05). Urinary kynurenine excretion in the luteal phase (81.6 +/- 14.4 mumol/24 h) was 28% greater than in the follicular phase (63.9 +/- 13.0 mumol/24 h) (p less than 0.05). The results indicate that the catabolism of Trp via the kynurenine pathway is affected by the phase of the human menstrual cycle.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0002916523435137; http://dx.doi.org/10.1093/ajcn/50.1.46; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024351991&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2750695; https://linkinghub.elsevier.com/retrieve/pii/S0002916523435137; https://dx.doi.org/10.1093/ajcn/50.1.46
Elsevier BV
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