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Pteroylpolyglutamates in human milk

The American Journal of Clinical Nutrition, ISSN: 0002-9165, Vol: 53, Issue: 4, Page: 930-934
1991
  • 46
    Citations
  • 0
    Usage
  • 11
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    46
    • Citation Indexes
      41
    • Policy Citations
      4
      • 4
    • Clinical Citations
      1
      • PubMed Guidelines
        1
  • Captures
    11

Article Description

Considerable variation exists in reported values for total folate content and the pteroylpolyglutamate (PteGlu n ) content of human milk. We investigated possible methodological sources of this variation. In two laboratories, milk folate content (with and without folate conjugase) was determined microbiologically. No differences in total milk folate or PteGlu n ( n > 3) content were found between laboratories. PteGlu n was found to comprise a significant fraction of total milk folate (28%). Use of rennin did not alter total folate content nor the percent of PteGlu n in human milk. Heating (121 °C for 5 min) increased folate concentrations (190%, P < 0.0001), indicating that release of folate from binding protein is necessary for folate utilization by Lactobacillus casei. Although human milk folate conjugase, (FC) activity was approximately one-twentieth that of plasma FC activity, it was not sufficient to autolyze endogenous PteGlu n. Thus, microbiological protocols that do not use folate conjugase and do not release folate from binding proteins will seriously underestimate milk folate values.

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