Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism 2
The American Journal of Clinical Nutrition, ISSN: 0002-9165, Vol: 82, Issue: 3, Page: 559-567
2005
- 419Citations
- 347Captures
- 8Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations419
- Citation Indexes418
- 418
- CrossRef330
- Policy Citations1
- Policy Citation1
- Captures347
- Readers347
- 326
- 21
- Mentions8
- News Mentions6
- News6
- References2
- Wikipedia2
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Article Description
Background: Resistant starch may modulate insulin sensitivity, although the precise mechanism of this action is unknown. Objective: We studied the effects of resistant starch on insulin sensitivity and tissue metabolism. Design: We used a 4-wk supplementation period with 30 g resistant starch/d, compared with placebo, in 10 healthy subjects and assessed the results by using arteriovenous difference methods. Results: When assessed by euglycemic-hyperinsulinemic clamp, insulin sensitivity was higher after resistant starch supplementation than after placebo treatment (9.7 and 8.5 × 10 −2 mg glucose · kg −1 · min −1 · (mU insulin/L) −1, respectively; P = 0.03); insulin sensitivity during the meal tolerance test (MTT) was 33% higher ( P = 0.05). Forearm muscle glucose clearance during the MTT was also higher after resistant starch supplementation ( P = 0.03) despite lower insulin concentrations ( P = 0.02); glucose clearance adjusted for insulin was 44% higher. Subcutaneous abdominal adipose tissue nonesterified fatty acid (NEFA; P = 0.02) and glycerol ( P = 0.05) release were lower with resistant starch supplementation, although systemic NEFA concentrations were not significantly altered. Short-chain fatty acid concentrations (acetate and propionate) were higher during the MTT ( P = 0.05 and 0.01, respectively), as was acetate uptake by adipose tissue ( P = 0.03). Fasting plasma ghrelin concentrations were higher with resistant starch supplementation (2769 compared with 2062 pg/mL; P = 0.03), although postprandial suppression (40–44%) did not differ significantly. Measurements of gene expression in adipose tissue and muscle were uninformative, which suggests effects at a metabolic level. The resistant starch supplement was well tolerated. Conclusion: These results suggest that dietary supplementation with resistant starch has the potential to improve insulin sensitivity. Further studies in insulin-resistant persons are needed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0002916523296021; http://dx.doi.org/10.1093/ajcn.82.3.559; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27244434038&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16155268; https://academic.oup.com/ajcn/article/82/3/559/4607459; https://academic.oup.com/ajcn/article/82/3/559/4862973; http://dx.doi.org/10.1093/ajcn/82.3.559; https://dx.doi.org/10.1093/ajcn.82.3.559
Oxford University Press (OUP)
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