Serum steroid and sex hormone-binding globulin concentrations and the risk of incident benign prostatic hyperplasia: Results from the Prostate Cancer Prevention Trial
American Journal of Epidemiology, ISSN: 0002-9262, Vol: 168, Issue: 12, Page: 1416-1424
2008
- 66Citations
- 77Captures
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Metrics Details
- Citations66
- Citation Indexes66
- 66
- CrossRef37
- Captures77
- Readers77
- 77
Article Description
The authors conducted a nested case-control study of serum steroid concentrations and risk of benign prostatic hyperplasia (BPH), using data from the placebo arm of the Prostate Cancer Prevention Trial (1993-2003). Incident BPH over 7 years (n = 708) was defined as receipt of treatment, a report of 2 International Prostate Symptom Score (IPSS) values greater than 14, or 2 increases of 5 or more from baseline IPSS values with at least 1 value greater than or equal to 12. Controls (n = 709) were selected from men who reported no BPH treatment or any IPSS greater than 7. Baseline serum was analyzed for testosterone, estradiol, estrone, 5α-androstane-3α, 17β-diol-glucuronide, and sex hormone-binding globulin. Covariate-adjusted odds ratios contrasting the highest quartiles with the lowest quartiles of testosterone, estradiol, and testosterone:17β-diol-glucuronide ratio were 0.64 (95% confidence interval (CI): 0.43, 0.95; P = 0.04), 0.72 (95% CI: 0.53, 0.98; P = 0.09), and 0.64 (95% CI: 0.46, 0.89; P = 0.004), respectively. Findings did not differ by age, body mass index, time to BPH endpoint, or type of BPH endpoint. High testosterone levels, estradiol levels, and testosterone:17β-diol-glucuronide ratio are associated with reduced BPH risk, which may reflect decreased activity of 5-α-reductase. Genetic or environmental factors that affect the activity of 5-α-reductase may be important in the development of symptomatic BPH. © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=57749180591&origin=inward; http://dx.doi.org/10.1093/aje/kwn272; http://www.ncbi.nlm.nih.gov/pubmed/18945688; https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwn272; https://dx.doi.org/10.1093/aje/kwn272; https://academic.oup.com/aje/article-abstract/168/12/1416/155496?redirectedFrom=fulltext
Oxford University Press (OUP)
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