Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: The CUMAGAA-CLL information system
American Journal of Epidemiology, ISSN: 0002-9262, Vol: 170, Issue: 6, Page: 671-678
2009
- 19Citations
- 20Captures
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Metrics Details
- Citations19
- Citation Indexes19
- CrossRef19
- 19
- Captures20
- Readers20
- 20
Article Description
A comprehensive and systematic assessment of the current status of candidate-gene association studies for chronic lymphocytic leukemia (CLL) was conducted. Data from 989 candidate-gene association studies (1992-2009) involving 905 distinct genetic variants were analyzed and cataloged in CUMAGAS-CLL, a Web-based information system which allows the retrieval and synthesis of data from candidate-gene association studies on CLL (http://biomath.med.uth.gr). Nine genetic variants (BAX (rs4645878), GSTM1 (null/present), GSTT1 (null/present), IL10 (rs1800896), LTA (rs909253), MTHFR (rs1801131), MTHFR (rs1801133), P2RX7 (rs3751143), and TNF (rs1800629)) were investigated in 4 or more studies, and their results were meta-analyzed. In individual studies, 147 variants showed a significant association with CLL risk under any genetic model. For 53 variants, the association was significant at P < 0.01 with an increased risk greater than 40%. Only 0.3% of studies had statistical power greater than 80%. In meta-analyses, none of the variants showed significant results, and heterogeneity ranged from none to high. Large and rigorous genetic studies (candidate-gene association studies and genome-wide association studies) designed to investigate epistatic and gene-environment interactions may produce more conclusive evidence about the genetic etiology of CLL. CUMAGAS-CLL would be a useful tool for current genomic epidemiology research in the field of CLL.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=69949114882&origin=inward; http://dx.doi.org/10.1093/aje/kwp201; http://www.ncbi.nlm.nih.gov/pubmed/19700502; https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp201; https://dx.doi.org/10.1093/aje/kwp201; https://academic.oup.com/aje/article-abstract/170/6/671/124094?redirectedFrom=fulltext
Oxford University Press (OUP)
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