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Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast

Bioscience, Biotechnology and Biochemistry, ISSN: 1347-6947, Vol: 86, Issue: 6, Page: 775-779
2022
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Article Description

Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition effect. Based on the comparative analysis of these compounds, we propose that Tschimganine has at least 2 targets: one extends the lifespan and the other inhibits growth.

Bibliographic Details

Ohtsuka, Hokuto; Matsumoto, Takuma; Mochida, Takahiro; Shimasaki, Takafumi; Shibuya, Masatoshi; Yamamoto, Yoshihiko; Aiba, Hirofumi

Informa UK Limited

Medicine

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