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Exploration and utilization of novel aldoxime, nitrile, and nitro compounds metabolizing enzymes from plants and arthropods

Bioscience, Biotechnology and Biochemistry, ISSN: 1347-6947, Vol: 88, Issue: 2, Page: 138-146
2024
  • 3
    Citations
  • 0
    Usage
  • 12
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    3
  • Captures
    12
  • Mentions
    1
    • News Mentions
      1
      • News
        1

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Toyama Prefectural University Reports Findings in Biotechnology and Biochemistry (Exploration and utilization of novel aldoxime, nitrile, and nitro compounds metabolizing enzymes from plants and arthropods)

2023 DEC 11 (NewsRx) -- By a News Reporter-Staff News Editor at Japan Daily Report -- New research on Biotechnology - Biotechnology and Biochemistry is

Review Description

Aldoxime (RRC=NOH) and nitrile (R-C≡N) are nitrogen-containing compounds that are found in species representing all kingdoms of life. The enzymes discovered from the microbial “aldoxime-nitrile” pathway (aldoxime dehydratase, nitrile hydratase, amidase, and nitrilase) have been thoroughly studied because of their industrial importance. Although plants utilize cytochrome P450 monooxygenases to produce aldoxime and nitrile, many biosynthetic pathways are yet to be studied. Cyanogenic millipedes accumulate various nitrile compounds, such as mandelonitrile. However, no such aldoxime- and nitrile-metabolizing enzymes have been identified in millipedes. Here, I review the exploration of novel enzymes from plants and millipedes with characteristics distinct from those of microbial enzymes, the catalysis of industrially useful reactions, and applications of these enzymes for nitrile compound production.

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