Ortholog identification in the presence of domain architecture rearrangement
Briefings in Bioinformatics, ISSN: 1467-5463, Vol: 12, Issue: 5, Page: 413-422
2011
- 24Citations
- 153Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef22
- Captures153
- Readers153
- 153
Article Description
Ortholog identification is used in gene functional annotation, species phylogeny estimation, phylogenetic profile construction and many other analyses. Bioinformatics methods for ortholog identification are commonly based on pairwise protein sequence comparisons between whole genomes. Phylogenetic methods of ortholog identification have also been developed; these methods can be applied to protein data sets sharing a common domain architecture or which share a single functional domain but differ outside this region of homology. While promiscuous domains represent a challenge to all orthology prediction methods, overall structural similarity is highly correlated with proximity in a phylogenetic tree, conferring a degree of robustness to phylogenetic methods. In this article, we review the issues involved in orthology prediction when data sets include sequences with structurally heterogeneous domain architectures, with particular attention to automated methods designed for high-throughput application, and present a case study to illustrate the challenges in this area. © The Author(s) 2011. Published by Oxford University Press.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053212413&origin=inward; http://dx.doi.org/10.1093/bib/bbr036; http://www.ncbi.nlm.nih.gov/pubmed/21712343; https://academic.oup.com/bib/article-lookup/doi/10.1093/bib/bbr036; https://dx.doi.org/10.1093/bib/bbr036; https://academic.oup.com/bib/article/12/5/413/270147
Oxford University Press (OUP)
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