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Crypt4GH: A file format standard enabling native access to encrypted data

Bioinformatics, ISSN: 1460-2059, Vol: 37, Issue: 17, Page: 2753-2754
2021
  • 8
    Citations
  • 0
    Usage
  • 17
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Motivation: The majority of genome analysis tools and pipelines require data to be decrypted for access. This potentially leaves sensitive genetic data exposed, either because the unencrypted data is not removed after analysis, or because the data leaves traces on the permanent storage medium. Results: : We defined a file container specification enabling direct byte-level compatible random access to encrypted genetic data stored in community standards such as SAM/BAM/CRAM/VCF/BCF. By standardizing this format, we show how it can be added as a native file format to genomic libraries, enabling direct analysis of encrypted data without the need to create a decrypted copy.

Bibliographic Details

Alexander Senf; Robert Davies; Frédéric Haziza; John Marshall; Juan Troncoso-Pastoriza; Oliver Hofmann; Thomas M. Keane; Peter Robinson

Oxford University Press (OUP)

Mathematics; Biochemistry, Genetics and Molecular Biology; Computer Science

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