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BenchStab: a tool for automated querying of web-based stability predictors

Bioinformatics, ISSN: 1367-4811, Vol: 40, Issue: 9
2024
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Article Description

Summary: Protein design requires information about how mutations affect protein stability. Many web-based predictors are available for this purpose, yet comparing them or using them en masse is difficult. Here, we present BenchStab, a console tool/Python package for easy and quick execution of 19 predictors and result collection on a list of mutants. Moreover, the tool is easily extensible with additional predictors. We created an independent dataset derived from the FireProtDB and evaluated 24 different prediction methods.

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