PlumX Metrics
Embed PlumX Metrics

TISIDB: An integrated repository portal for tumor-immune system interactions

Bioinformatics, ISSN: 1460-2059, Vol: 35, Issue: 20, Page: 4200-4202
2019
  • 1,483
    Citations
  • 0
    Usage
  • 176
    Captures
  • 10
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Most Recent News

Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer

Introduction Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second leading cause of cancer-related mortality.1 Despite advancements in early

Article Description

The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were precalculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.

Bibliographic Details

Beibei Ru; Ching Ngar Wong; Yin Tong; Jia Yi Zhong; Sophia Shek Wa Zhong; Wai Chung Wu; Ka Chi Chu; Choi Yiu Wong; Chit Ying Lau; Ian Chen; Nam Wai Chan; Jiangwen Zhang; Jonathan Wren

Oxford University Press (OUP)

Mathematics; Biochemistry, Genetics and Molecular Biology; Computer Science

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know