Activity-dependent ATP-waves in the mouse neocortex are independent from astrocytic calcium waves
Cerebral Cortex, ISSN: 1047-3211, Vol: 16, Issue: 2, Page: 237-246
2006
- 116Citations
- 137Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations116
- Citation Indexes116
- 116
- CrossRef68
- Captures137
- Readers137
- 137
Article Description
In the corpus callosum, astrocytic calcium waves propagate via a mechanism involving ATP-release but not gap junctional coupling. In the present study, we report for the neocortex that calcium wave propagation depends on functional astrocytic gap junctions but is still accompanied by ATP-release. In acute slices obtained from the neocortex of mice deficient for astrocytic expression of connexin43, the calcium wave did not propagate. In contrast, in the corpus callosum and hippocampus of these mice, the wave propagated as in control animals. In addition to calcium wave propagation in astrocytes, ATP-release was recorded as a calcium signal from 'sniffer cells', a cell line expressing high-affinity purinergic receptors placed on the surface of the slice. The astrocyte calcium wave in the neocortex was accompanied by calcium signals in the 'sniffer cell' population. In the connexin43-deficient mice we recorded calcium signals from sniffer cells also in the absence of an astrocytic calcium wave. Our findings indicate that astrocytes propagate calcium signals by two separate mechanisms depending on the brain region and that ATP release can propagate within the neocortex independent from calcium waves. © The Author 2005. Published by Oxford University Press. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=30744450905&origin=inward; http://dx.doi.org/10.1093/cercor/bhi101; http://www.ncbi.nlm.nih.gov/pubmed/15930372; http://academic.oup.com/cercor/article/16/2/237/281544/Activitydependent-ATPwaves-in-the-Mouse-Neocortex; https://dx.doi.org/10.1093/cercor/bhi101; https://academic.oup.com/cercor/article-abstract/16/2/237/281544?redirectedFrom=fulltext
Oxford University Press (OUP)
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