Dendritic spine morphology determines membrane-associated protein exchange between dendritic shafts and spine heads
Cerebral Cortex, ISSN: 1047-3211, Vol: 19, Issue: 3, Page: 697-702
2009
- 17Citations
- 70Captures
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef15
- Captures70
- Readers70
- 70
Article Description
The purpose of this study was to examine whether variability in the shape of dendritic spines affects protein movement within the plasma membrane. Using a combination of confocal microscopy and the fluorescence loss in photobleaching technique in living hippocampal CA1 pyramidal neurons expressing membrane-linked GFP, we observed a clear correlation between spine shape parameters and the diffusion and compartmentalization of membrane-associated proteins. The kinetics of membrane-linked GFP exchange between the dendritic shaft and the spine head compartment were slower in dendritic spines with long necks and/or large heads than in those with short necks and/or small heads. Furthermore, when the spine area was reduced by eliciting epileptiform activity, the kinetics of protein exchange between the spine compartments exhibited a concomitant decrease. As synaptic plasticity is considered to involve the dynamic flux by lateral diffusion of membrane-bound proteins into and out of the synapse, our data suggest that spine shape represents an important parameter in the susceptibility of synapses to undergo plastic change. © The Author 2008. Published by Oxford University Press. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59749086557&origin=inward; http://dx.doi.org/10.1093/cercor/bhn118; http://www.ncbi.nlm.nih.gov/pubmed/18653666; https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhn118; https://dx.doi.org/10.1093/cercor/bhn118; https://academic.oup.com/cercor/article-abstract/19/3/697/436077?redirectedFrom=fulltext
Oxford University Press (OUP)
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