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Detection of infectious influenza virus in cough aerosols generated in a simulated patient examination room

Clinical Infectious Diseases, ISSN: 1058-4838, Vol: 54, Issue: 11, Page: 1569-1577
2012
  • 160
    Citations
  • 0
    Usage
  • 197
    Captures
  • 5
    Mentions
  • 40
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    160
    • Citation Indexes
      150
    • Policy Citations
      9
      • Policy Citation
        9
    • Clinical Citations
      1
      • PubMed Guidelines
        1
  • Captures
    197
  • Mentions
    5
    • News Mentions
      3
      • News
        3
    • Blog Mentions
      2
      • Blog
        2
  • Social Media
    40
    • Shares, Likes & Comments
      40
      • Facebook
        40

Most Recent News

Maximizing Fit for Cloth and Medical Procedure Masks to Improve Performance and Reduce SARS-CoV-2 Transmission and Exposure, 2021

On February 10, 2021, this report was posted online as an MMWR Early Release. Please note:. This report has been corrected. John T. Brooks, MD1;

Article Description

Background.The potential for aerosol transmission of infectious influenza virus (ie, in healthcare facilities) is controversial. We constructed a simulated patient examination room that contained coughing and breathing manikins to determine whether coughed influenza was infectious and assessed the effectiveness of an N95 respirator and surgical mask in blocking transmission.Methods.National Institute for Occupational Safety and Health aerosol samplers collected size-fractionated aerosols for 60 minutes at the mouth of the breathing manikin, beside the mouth, and at 3 other locations in the room. Total recovered virus was quantitated by quantitative polymerase chain reaction and infectivity was determined by the viral plaque assay and an enhanced infectivity assay.Results.Infectious influenza was recovered in all aerosol fractions (5.0% in >4 μm aerodynamic diameter, 75.5% in 1-4 μm, and 19.5% in <1 μm; n = 5). Tightly sealing a mask to the face blocked entry of 94.5% of total virus and 94.8% of infectious virus (n = 3). A tightly sealed respirator blocked 99.8% of total virus and 99.6% of infectious virus (n = 3). A poorly fitted respirator blocked 64.5% of total virus and 66.5% of infectious virus (n = 3). A mask documented to be loosely fitting by a PortaCount fit tester, to simulate how masks are worn by healthcare workers, blocked entry of 68.5% of total virus and 56.6% of infectious virus (n = 2).Conclusions.These results support a role for aerosol transmission and represent the first reported laboratory study of the efficacy of masks and respirators in blocking inhalation of influenza in aerosols. The results indicate that a poorly fitted respirator performs no better than a loosely fitting mask. © 2012 The Author.

Bibliographic Details

Noti, John D; Lindsley, William G; Blachere, Francoise M; Cao, Gang; Kashon, Michael L; Thewlis, Robert E; McMillen, Cynthia M; King, William P; Szalajda, Jonathan V; Beezhold, Donald H

Oxford University Press (OUP)

Medicine

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