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Some features of the mutability of bacteria during nonlethal selection

Genetics, ISSN: 0016-6731, Vol: 154, Issue: 1, Page: 49-59
2000
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Article Description

We describe the mutability of the Trp chromosomal +1 frameshift mutation trpE7999 during nonlethal selection, finding that the appearance of Trp revertants behaves similarly to that of episomal Lac revertants. In addition, we show that a feature of the Lac and Trp mutability is the accumulation of Trp and Lac revertants with additional unselected mutations, most of which are not due to heritable mutators. The cells undergoing nonlethal selection apparently experience an epigenetic change resulting in a subset of bacteria with elevated mutability that often remain hypermutable for the duration of selection. The epigenetic change provoked by nonlethal selection appears to be mediated by a unique function provided by the F'128 episome.

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