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Lower Impact of Disease on Daily Life and Less Fatigue in Patients With Inflammatory Bowel Disease Following a Lifestyle Intervention

Inflammatory Bowel Diseases, ISSN: 1536-4844, Vol: 28, Issue: 12, Page: 1791-1799
2022
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Background: Despite the potential benefits of diet and physical activity, evidence for beneficial effects of a combined lifestyle intervention is lacking in patients with inflammatory bowel disease (IBD). Therefore, we assessed its effects on impact of disease on daily life, clinical disease activity, fatigue, and health-related quality of life (HRQoL) in patients with IBD. Methods: A 6-month single-arm intervention study was performed in adult IBD patients in remission or with mildly active disease. Participants received personal dietary and physical activity advice from a dietician and a physiotherapist in 6 consults. At baseline and over time, questionnaires on diet quality, physical activity, and disease-related outcomes were completed and fecal calprotectin was determined. Data were analyzed by linear mixed models. Results: During the intervention, diet quality significantly increased (P <. 001), but the level of physical activity remained the same. Over time, impact of the disease on daily life reduced (P =. 009) and fatigue decreased (P =. 001), while clinical disease activity, HRQoL, and fecal calprotectin did not change. Improvement in diet quality was significantly associated with a lower impact of disease on daily life (β = 0.09; 95% confidence interval [CI], 0.03 to 0.15; P =. 003) and less fatigue (β = -0.13; 95% CI, -0.20 to -0.07; P <. 001) but not with clinical disease activity, HRQoL, and fecal calprotectin. No associations were found with physical activity. Conclusions: This combined lifestyle intervention significantly improved diet quality, and this improvement was associated with a reduction in the impact of disease on daily life and fatigue in patients with IBD in remission or with mildly active disease.

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