Risk factors across the life course and dementia in a Brazilian population: Results from the Sao Paulo Ageing & Health Study (SPAH)
International Journal of Epidemiology, ISSN: 0300-5771, Vol: 37, Issue: 4, Page: 879-890
2008
- 78Citations
- 139Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations78
- Citation Indexes78
- 78
- CrossRef47
- Captures139
- Readers139
- 139
Article Description
Background: Several mechanisms have been suggested to explain the association between adversities across life and dementia. This study aimed to investigate the association between indicators of socioeconomic disadvantages throughout the life-course and dementia among older adults in Sao Paulo, Brazil and to explore possible causal pathways. Methods: We used baseline data from the SPAH study which involved participants aged 65 years and older (n = 2005). The outcome of interest was prevalent dementia. Exposures included in the analyses were socioeconomic position (SEP) indicators in childhood (place of birth and literacy) and adulthood (occupation and income), anthropometric measurements as markers of intrauterine and childhood environment (head circumference and leg length), smoking, diabetes and hypertension. Logistic regression models were used to test the hypothesized pathways and to assess whether there was an association between cumulative adversities across the life course and prevalent dementia. Results: Indicators of socioeconomic disadvantage in early life were associated with increased prevalence of dementia. This association was partially mediated through adulthood SEP. Head circumference and leg length were also clearly associated with dementia but there was no evidence that this association was mediated by early life socioeconomic disadvantage. There was an association between cumulative unfavourable conditions across the life course and dementia. Conclusions: Early life disadvantages seem to operate through biological mechanisms associated with passive brain reserve and opportunities in life representing active cognitive reserve. Prevention of dementia should start early in life and continue through life span as seen with many other chronic diseases. © The Author 2008; all rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=48349134889&origin=inward; http://dx.doi.org/10.1093/ije/dyn125; http://www.ncbi.nlm.nih.gov/pubmed/18583392; https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyn125; https://dx.doi.org/10.1093/ije/dyn125; https://academic.oup.com/ije/article-abstract/37/4/879/738761?redirectedFrom=fulltext; http://ije.oxfordjournals.org/content/37/4/879; https://academic.oup.com/ije/article-pdf/37/4/879/2208203/dyn125.pdf; https://academic.oup.com/ije/article/37/4/879/738761; http://research-repository.uwa.edu.au/en/publications/risk-factors-across-the-life-course-and-dementia-in-a-brazilian-population-results-from-the-sao-paulo-ageing--health-study-spah(d4f3e08b-f4e5-496f-818c-cfcb1a8a21cb).html; https://research-repository.uwa.edu.au/en/publications/risk-factors-across-the-life-course-and-dementia-in-a-brazilian-p; https://academic.oup.com/ije/article/37/4/879/738761/Risk-factors-across-the-life-course-and-dementia; http://ije.oxfordjournals.org/lookup/doi/10.1093/ije/dyn125; http://europepmc.org/abstract/med/18583392; http://www.ije.oxfordjournals.org/cgi/doi/10.1093/ije/dyn125; https://academic.oup.com/ije; https://research-repository.uwa.edu.au/en/publications/risk-factors-across-the-life-course-and-dementia-in-a-brazilian-population-results-from-the-sao-paulo-ageing--health-study-spah(d4f3e08b-f4e5-496f-818c-cfcb1a8a21cb).html; http://ije.oxfordjournals.org/cgi/doi/10.1093/ije/dyn125; https://research-repository.uwa.edu.au/en/publications/d4f3e08b-f4e5-496f-818c-cfcb1a8a21cb
Oxford University Press (OUP)
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