Zinc intake and risk of Crohn's disease and ulcerative colitis: A prospective cohort study
International Journal of Epidemiology, ISSN: 1464-3685, Vol: 44, Issue: 6, Page: 1995-2005
2015
- 88Citations
- 113Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations88
- Citation Indexes88
- 88
- CrossRef19
- Captures113
- Readers113
- 113
Article Description
Background: Diet plays a role in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). Dietary zinc may influence risk of disease through effects on autophagy, innate and adaptive immune response and maintenance of the intestinal barrier. Methods: We analysed data from 170 776 women from the Nurses Health Study I and Nurses Health Study II, who were followed for 26 years. Zinc intake was assessed using semi-quantitative food frequency questionnaires administered every 4 years. Incident CD and UC were ascertained by medical record review. Cox proportional hazards models adjusting for potential confounders determined the independent association between zinc intake and incident disease. Results: Over 3 317 550 person-years (p-y) of follow-up, we identified 269 incident cases of CD and 338 incident cases of UC. Zinc intake ranged from 9mg/day in the lowest quintile to 27 mg/day in the highest quintile. Compared with women with the lowest quintile of intake, the multivariate hazard ratios (HR) for CD were 0.92 [95% confidence interval (CI), 0.65 - 1.29) for women in the second quintile of intake, 0.60 (95% CI, 0.40 - 0.89) for the third quintile, 0.57 (95% CI, 0.38 - 0.86) for fourth quintile and 0.74 (95% CI, 0.50 - 1.10) for the highest quintile (P=0.003). The association was stronger for dietary zinc (HR 0.63, 95% CI, 0.43 - 0.93, comparing extreme quintiles) than for zinc intake from supplements. Neither dietary nor supplemental zinc modified risk of UC. Conclusions: In two large prospective cohorts of women, intake of zinc was inversely associated with risk of CD but not UC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84962775899&origin=inward; http://dx.doi.org/10.1093/ije/dyv301; http://www.ncbi.nlm.nih.gov/pubmed/26546032; https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyv301; https://dx.doi.org/10.1093/ije/dyv301; https://academic.oup.com/ije/article/44/6/1995/2572627
Oxford University Press (OUP)
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