Improved pregnancy outcomes in women exposed to malaria with high antibody levels against plasmodium falciparum
Journal of Infectious Diseases, ISSN: 0022-1899, Vol: 207, Issue: 11, Page: 1664-1674
2013
- 38Citations
- 98Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations38
- Citation Indexes38
- 38
- CrossRef29
- Captures98
- Readers98
- 98
- Mentions1
- News Mentions1
- 1
Most Recent News
VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.(RESEARCH)
Agile malaria surveillance and response systems that can be sustained over time are needed for the optimal design of control programs (1,2). Rates of Plasmodium
Article Description
Background. Antibodies against VAR2CSA, the Plasmodium falciparum variant surface antigen that binds placental chondroitin sulfate A, have been suggested to mediate protection against malaria in pregnancy but also to be markers of infection. Here, we aimed to identify clinically relevant antibody responses, taking into consideration variations in parasite exposure and human immunodeficiency virus type 1 (HIV) infection status.Methods. Levels of immunoglobulin G (IgG) against placental and pediatric isolates, VAR2CSA (DBL2X, DBL3X, DBL5, and DBL6η domains), and other blood-stage antigens (DBLγ;, DBLα, MSP1, AMA1, and EBA175) were measured in plasma specimens from 293 pregnant Mozambican women at delivery. Associations between antibody responses, factors influencing malaria exposure, HIV infection status, and pregnancy outcomes were assessed.Results. Maternal antibodies were affected by placental infection, parity, season, and neighborhood of residence. HIV infection modified these associations and attenuated the parity-dependent increase in IgG level. High levels of antibody against AMA1, DBL3X, DBL6η, placental isolates, and pediatric isolates were associated with increased weight and gestational age of newborns (P ≤. 036) among women with malaria episodes during pregnancy.Conclusions. Antiparasite IgGs in women at delivery are affected by HIV infection, as well as by variations in the exposure to P. falciparum. Heterogeneity of malaria transmission needs to be considered to identify IgGs against VAR2CSA and other parasite antigens associated with improved pregnancy outcomes. © 2013 The Author.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877271841&origin=inward; http://dx.doi.org/10.1093/infdis/jit083; http://www.ncbi.nlm.nih.gov/pubmed/23448726; https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jit083; https://dx.doi.org/10.1093/infdis/jit083; https://academic.oup.com/jid/article/207/11/1664/796149
Oxford University Press (OUP)
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