Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: A case report
Journal of Antimicrobial Chemotherapy, ISSN: 0305-7453, Vol: 56, Issue: 4, Page: 787-789
2005
- 35Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations35
- Citation Indexes33
- 33
- CrossRef19
- Policy Citations2
- Policy Citation2
- Captures26
- Readers26
- 26
Article Description
Objectives: Linezolid is an oxazolidinone antibiotic used in the treatment of infections caused by vancomycin-resistant enterococci. Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. Patient and methods: We present clinical details and susceptibility data from multiple Enterococcus faecium strains isolated from a liver transplant patient over 13 months. MICs of linezolid, vancomycin and quinupristin/dalfopristin were determined using Etest. Molecular typing was performed by pulsed-field gel electrophoresis. Domain V of the 23S rRNA gene in the vancomycin-resistant Enterococcus faecium was amplified. Linezolid concentrations were analysed by HPLC. Results: We report the emergence of resistance to linezolid in a vancomycin-resistant Enterococcus faecium during linezolid treatment. After discontinuation of the linezolid therapy, the isolate reverted to susceptibility. However, after re-administration of linezolid the vancomycin-resistant Enterococcus faecium became resistant to linezolid again. The isolates that were resistant to linezolid had a G2576T mutation in their 23S rDNA. Conclusion: We describe a clinical case that shows the shift of a vancomycin-resistant Enterococcus faecium from linezolid resistance to susceptibility and then back to resistance again related to linezolid therapy. © The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27144479859&origin=inward; http://dx.doi.org/10.1093/jac/dki318; http://www.ncbi.nlm.nih.gov/pubmed/16143710; http://academic.oup.com/jac/article/56/4/787/769497/Varying-linezolid-susceptibility-of; https://dx.doi.org/10.1093/jac/dki318; https://academic.oup.com/jac/article-abstract/56/4/787/769497?redirectedFrom=fulltext
Oxford University Press (OUP)
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