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Pristinamycin: Old drug, new tricks?

Journal of Antimicrobial Chemotherapy, ISSN: 1460-2091, Vol: 69, Issue: 9, Page: 2319-2325
2014
  • 27
    Citations
  • 0
    Usage
  • 46
    Captures
  • 0
    Mentions
  • 50
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    27
  • Captures
    46
  • Social Media
    50
    • Shares, Likes & Comments
      50
      • Facebook
        50

Article Description

Osteoarticular infections with Gram positive bacteria present an increasing challenge in an era of multidrugresistant organisms. Prolonged intravenous antibiotic treatment is often required, with associated risks, costs and difficulties with administration; a safe, effective oral option would be ideal for this indication. Pristinamycin, an oral streptogramin antibiotic with bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus, has been used for over 50 years in Europe for the treatment of osteoarticular infections. We review the published evidence for the treatment of native bone and prosthesisrelated osteoarticular infections with pristinamycin. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

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