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Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients: The SAVE study, 2011-15

Journal of Antimicrobial Chemotherapy, ISSN: 1460-2091, Vol: 73, Issue: suppl_7, Page: vii5-vii11
2018
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Article Description

Objectives: To assess antimicrobial susceptibility for 14 agents tested against 6001 invasive isolates of Streptococcus pneumoniae cultured from invasive patient samples from 2011 to 2015 as a part of the annual SAVE study. Methods: Isolates of S. pneumoniae were tested using the standard CLSI broth microdilution method (M07-A10, 2015) with MICs interpreted by CLSI M100 27th Edition (2017) MIC breakpoints. Results: From2011 to 2015, small but significant increases (P≤0.05) in the percentage susceptibility for penicillin (interpreted by all three CLSI MIC breakpoint criteria) (increase of 1.7%-3.2%), clindamycin (3.1%) and ceftriaxone (interpreted by non-meningitis and meningitis CLSI MIC breakpoint criteria) (1.1%-1.5%) were observed. Susceptibility rates for clarithromycin and other commonly tested antimicrobial agents remained unchanged (P > 0.05) over the 5 year period. Isolates with an MDR phenotype (resistance to three or more antimicrobial agent classes) decreased significantly (P < 0.001) from 8.5% in 2011 to 5.6% in 2015. Antimicrobial susceptibility rates were not generally associated (P < 0.05) with patient gender (exception: clarithromycin) but were associated (P ≤ 0.05) with patient age (chloramphenicol and clindamycin) or specimen source (penicillin, doxycycline, trimethoprim/sulfamethoxazole and clindamycin), as well as geographic location in Canada and concurrent resistance to penicillin or clarithromycin. Conclusions: The in vitro susceptibility of invasive isolates of S. pneumoniae in Canada to penicillin, clindamycin and ceftriaxone increased from2011 to 2015, coincident with a significant decrease in MDR phenotypes.

Bibliographic Details

Karlowsky, James A; Adam, Heather J; Golden, Alyssa R; Baxter, Melanie R; Nichol, Kim A; Martin, Irene; Demczuk, Walter; Mulvey, Michael R; Gilmour, Matthew W; Hoban, Daryl J; Zhanel, George G; Canadian Antimicrobial Resistance Alliance (CARA)

Oxford University Press (OUP)

Pharmacology, Toxicology and Pharmaceutics; Medicine

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