Transport of bacterial toxins into target cells: Pathways followed by cholera toxin and botulinum progenitor toxin
Journal of Biochemistry, ISSN: 0021-924X, Vol: 140, Issue: 2, Page: 155-160
2006
- 32Citations
- 35Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef26
- Captures35
- Readers35
- 35
- Mentions1
- News Mentions1
- News1
Article Description
A number of bacterial toxins have sophisticated mechanisms for reaching their specific targets in mammalian cells, to exert their toxicity. This review focuses on the transport mechanisms of cholera toxin and botulinum neurotoxin complex. Cholera toxin is an ADP-ribosyltransferase toxin, and the covalent modification of heterotrimeric Gs protein in the cytosol leads to the activation of adenylyl cyclase and a sequence of events culminating in massive diarrheal disease. Here, we describe the structural features of this toxin and the transport pathway followed by this toxin from the plasma membrane to the cytosol of intestinal epithelial cells. Botulinum neurotoxin is a metalloprotease toxin that enters neurons, where it cleaves core proteins of the neuroexocytosis apparatus and elicits the inhibition of neurotransmitter release. The food-borne botulism is manifested when the neurotoxin is absorbed from the digestive tract, enters the blood stream, and reaches the cytosol of the peripheral nerves. We overview the structural organization and the long journey followed by this toxin. © 2006 The Japanese Biochemical Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750372422&origin=inward; http://dx.doi.org/10.1093/jb/mvj161; http://www.ncbi.nlm.nih.gov/pubmed/16954533; http://academic.oup.com/jb/article/140/2/155/806191/Transport-of-Bacterial-Toxins-into-Target-Cells; https://dx.doi.org/10.1093/jb/mvj161; https://academic.oup.com/jb/article-abstract/140/2/155/806191?redirectedFrom=fulltext
Oxford University Press (OUP)
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