Role of the unfolded protein response in the development of central nervous system
Journal of Biochemistry, ISSN: 1756-2651, Vol: 162, Issue: 3, Page: 155-162
2017
- 30Citations
- 93Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations30
- Citation Indexes28
- 28
- Clinical Citations1
- PubMed Guidelines1
- Policy Citations1
- 1
- Captures93
- Readers93
- 93
Review Description
The unfolded protein response (UPR) is an intracellular homeostatic signalling pathway that is induced by accumulated misfolded/unfolded proteins in the endoplasmic reticulum (ER). The UPR is closely associated with the development of disease in several tissues, including the central nervous system (CNS), in response to ER stress. More recently, the unique features and importance of the UPR have been revealed in neural stem cells (NSCs) and differentiated CNS cells [neurons and glial cells (astrocytes and oligodendrocytes)]. Although several UPR signalling pathways dynamically change in each CNS cell during brain development, the role of UPR signalling in CNS cells (especially NSCs and glial cells) under pathological or physiological conditions is poorly understood. Here, we discuss and summarize the recent progress in understanding how the UPR regulates the proliferation, differentiation, maturation and viability of CNS cells.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85031697056&origin=inward; http://dx.doi.org/10.1093/jb/mvx047; http://www.ncbi.nlm.nih.gov/pubmed/28903548; http://academic.oup.com/jb/article/162/3/155/3980272/Role-of-the-unfolded-protein-response-in-the; https://dx.doi.org/10.1093/jb/mvx047; https://academic.oup.com/jb/article/162/3/155/3980272
Oxford University Press (OUP)
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