A Low Protein Diet Lowers Islet Insulin Secretion but Does Not Alter Hyperinsulinemia in Obese Zucker ( fa/fa ) Rats
The Journal of Nutrition, ISSN: 0022-3166, Vol: 125, Issue: 7, Page: 1923-1929
1995
- 7Citations
- 4Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations7
- Citation Indexes7
- CrossRef3
- Captures4
- Readers4
Article Description
The effects of feeding a low protein diet on pancreatic insulin secretion early in life in genetically lean and obese Zucker rats were studied. Four-week-old lean ( Fa/Fa ) and obese ( fa/fa ) Zucker rats were fed either a 5% protein or a 20% protein diet for 3 wk. Rats were killed at 7 wk of age. Pancreatic islets were isolated and insulin response of islets was measured in a 60-min static incubation under one of the following conditions: 2.7 mmol/L glucose ± 10 mmol/L arginine, 8.3 mmol/L glucose ± 10 mmol/L arginine, and 16.7 mmol/L glucose. Serum insulin was significantly lower ( P ≤ 0.05) in lean, but not in obese rats fed low protein compared with those fed the normal protein diet. Interestingly, obese rats fed the low protein diet had the highest plasma glucose concentrations ( P ≤ 0.05) among the four groups. Feeding the low protein diet reduced insulin secretion of islets from lean rats by 70%, and from obese rats by 30 to 50% compared with rats fed the normal protein diet. Insulin content of islets was reduced significantly in lean rats fed the low protein diet (by 70%) and in obese rats (by 50%). A short-term protein deficiency early in life reduced in vitro insulin secretion of islets from both lean and obese rats. However, reductions in insulin content and insulin release from islets resulting from low protein feeding were not sufficient to alter hyperinsulinemia in genetically obese Zucker rats.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022316623035393; http://dx.doi.org/10.1093/jn/125.7.1923; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029027297&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7616309; https://linkinghub.elsevier.com/retrieve/pii/S0022316623035393; https://dx.doi.org/10.1093/jn/125.7.1923
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know