Safety Assessment of Recombinant Green Fluorescent Protein Orally Administered to Weaned Rats
The Journal of Nutrition, ISSN: 0022-3166, Vol: 133, Issue: 6, Page: 1909-1912
2003
- 66Citations
- 70Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations66
- Citation Indexes52
- 52
- CrossRef47
- Policy Citations14
- 14
- Captures70
- Readers70
- 70
Article Description
Several proposed biotechnological applications of green fluorescent protein (GFP) are likely to result in its introduction into the food supply of domestic animals and humans. We fed pure GFP and diets containing transgenic canola expressing GFP to young male rats for 26 d to evaluate the potential toxicity and allergenicity of GFP. Animals ( n = 8 per group) were fed either AIN-93G (control), control diet plus 1.0 mg of purified GFP daily, modified control diet with 200 g/kg canola ( Brassica rapa cv Westar), or control diet with 200 g/kg transgenic canola containing one of two levels of GFP. Ingestion of GFP did not affect growth, food intake, relative weight of intestine or other organs, or activities of hepatic enzymes in serum. Comparison of the amino acid sequence of GFP to known food allergens revealed that the greatest number of consecutive amino acid matches between GFP and any food allergen was four, suggesting the absence of common allergen epitopes. Moreover, GFP was rapidly degraded during simulated gastric digestion. These data indicate that GFP is a low allergenicity risk and provide preliminary indications that GFP is not likely to represent a health risk.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S002231662215964X; http://dx.doi.org/10.1093/jn/133.6.1909; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0038314456&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12771338; https://linkinghub.elsevier.com/retrieve/pii/S002231662215964X; https://dx.doi.org/10.1093/jn/133.6.1909
Elsevier BV
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