Clues to mortality trends and their related factors in IgG4-related disease: A Japanese single-centre retrospective study
Modern Rheumatology, ISSN: 1439-7609, Vol: 33, Issue: 6, Page: 1154-1161
2023
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Article Description
Objectives: This study aimed to clarify mortality trends and their related factors in immunoglobulin G4-related disease (IgG4-RD) with various organ involvement. Methods: We retrospectively reviewed the medical records of patients with IgG4-RD at a single rheumatology centre in Japan. We calculated the standardized mortality ratio using Japanese national mortality statistics. Cox regression analyses were also performed to assess mortality-related factors. Results: A total of 179 patients with IgG4-RD were included with a median follow-up period of 47 months. The standardized mortality ratio in our cohort was 0.86 (95% confidence interval 0.41–1.59). Univariate Cox regression analyses indicated that the number of affected organs at diagnosis (hazard ratio 1.45, 95% confidence interval 1.02–2.05), estimated glomerular infiltration rate <45 ml/min/1.73 m at diagnosis (vs. ≥45, hazard ratio 8.48, 95% confidence interval 2.42–29.79), and the presence of malignancy during the clinical course (hazard ratio 5.85, 95% confidence interval 1.62–21.15) had a significant impact on the time to death. Conclusions: Our findings suggest that in the rheumatology department, IgG4-RD does not significantly affect long-term patient survival. However, multi-organ involvement, renal dysfunction, and malignancy may be associated with higher mortality trends in IgG4-RD. Early detection and appropriate management of risk factors may improve the long-term prognosis of patients with IgG4-RD.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85176496251&origin=inward; http://dx.doi.org/10.1093/mr/roac132; http://www.ncbi.nlm.nih.gov/pubmed/36300954; https://academic.oup.com/mr/article/33/6/1154/6775657; https://dx.doi.org/10.1093/mr/roac132; https://academic.oup.com/mr/article-abstract/33/6/1154/6775657?redirectedFrom=fulltext
Oxford University Press (OUP)
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