PlumX Metrics
Embed PlumX Metrics

Acrylamide genotoxicity in young versus adult gpt delta male rats

Mutagenesis, ISSN: 0267-8357, Vol: 26, Issue: 4, Page: 545-549
2011
  • 24
    Citations
  • 0
    Usage
  • 29
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The recent discovery that the potent carcinogen acrylamide (AA) is present in a variety of fried and baked foods raises health concerns, particularly for children, because AA is relatively high in child-favoured foods such as potato chips and French fries. To compare the susceptibility to AA-induced genotoxicity of young versus adult animals, we treated 3- and 11-week-old male gpt delta transgenic F344 rats with 0, 20, 40 or 80 p.p.m. AA via drinking water for 4 weeks and then examined genotoxicity in the bone marrow, liver and testis. We also analysed the level of N7-(2-carbamoyl-2-hydroxyethyl)-guanine (N7-GA-Gua), the major DNA adduct induced by AA, in the liver, testis and mammary gland. At 40 and 80 p.p.m., both age groups yield similar results in the comet assay in liver; but at 80 p.p.m., the bone marrow micronucleus frequency and the gpt-mutant frequency in testis increased significantly only in the young rats, and N7-GA-Gua adducts in the testis was significantly higher in the young rats. These results imply that young rats are more susceptible than adult rats to AA-induced testicular genotoxicity. © The Author 2011. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved.

Bibliographic Details

Koyama, Naoki; Yasui, Manabu; Kimura, Aoi; Takami, Shigeaki; Suzuki, Takuya; Masumura, Kenichi; Nohmi, Takehiko; Masuda, Shuichi; Kinae, Naohide; Matsuda, Tomonari; Imai, Toshio; Honma, Masamitsu

Oxford University Press (OUP)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine; Environmental Science

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know