Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
Nucleic Acids Research, ISSN: 0305-1048, Vol: 34, Issue: 17, Page: 4677-4684
2006
- 97Citations
- 47Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations97
- Citation Indexes97
- 97
- CrossRef84
- Captures47
- Readers47
- 47
Article Description
The human immunodeficiency virus (HIV) Vif protein blocks incorporation of two host cell cytidine deaminases, APOBEC3F and 3G, into the budding virion. Not surprisingly, on a vif background nascent minus strand DNA can be extensively edited leaving multiple uracil residues. Editing occurs preferentially in the context of TC (GA on the plus strand) and CC (GG) depending on the enzyme. To explore the distribution of APOBEC3F and -3G editing across the genome, a product/substrate ratio (AA + AG)/ (GA + GG) was computed for a series of 30 edited genomes present in the data bases. Two highly polarized gradients were noted each with maxima just 5′ to the central polypurine tract (cPPT) and LTR proximal polypurine tract (3′PPT). The gradients are in remarkable agreement with the time the minus strand DNA remains single stranded. In vitro analyses of APOBEC3G deamination of nascent cDNA spanning the two PPTs showed no pronounced dependence on the PPT RNA:DNA heteroduplex ruling out the competing hypothesis of a PPT orientation effect. The degree of hypermutation varied smoothly among genomes indicating that the number of APOBEC3 molecules packaged varied considerably. © 2006 Oxford University Press.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750210516&origin=inward; http://dx.doi.org/10.1093/nar/gkl555; http://www.ncbi.nlm.nih.gov/pubmed/16963778; https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkl555; https://dx.doi.org/10.1093/nar/gkl555; https://academic.oup.com/nar/article/34/17/4677/3111961
Oxford University Press (OUP)
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