MouseNet v2: A database of gene networks for studying the laboratory mouse and eight other model vertebrates
Nucleic Acids Research, ISSN: 1362-4962, Vol: 44, Issue: D1, Page: D848-D854
2016
- 33Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations33
- Citation Indexes33
- 33
- CrossRef6
- Captures24
- Readers24
- 24
Article Description
Laboratory mouse,Mus musculus, is one of the most important animal tools in biomedical research. Functional characterization of the mouse genes, hence, has been a long-standing goal in mammalian and human genetics. Although large-scale knockout phenotyping is under progress by international collaborative efforts, a large portion of mouse genome is still poorly characterized for cellular functions and associations with disease phenotypes. A genome-scale functional network of mouse genes, MouseNet, was previously developed in context of MouseFunc competition, which allowed only limited input data for network inferences. Here, we present an improved mouse co-functional network, MouseNet v2 (available at http://www.inetbio.org/mousenet), which covers 17 714 genes (>88% of coding genome) with 788 080 links, along with a companion web server for network-assisted functional hypothesis generation. The network database has been substantially improved by large expansion of genomics data. For example, MouseNet v2 database contains 183 coexpression networks inferred from 8154 public microarray samples. We demonstrated that MouseNet v2 is predictive for mammalian phenotypes as well as human diseases, which suggests its usefulness in discovery of novel disease genes and dissection of disease pathways. Furthermore, MouseNet v2 database provides functional networks for eight other vertebrate models used in various research fields.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84976870544&origin=inward; http://dx.doi.org/10.1093/nar/gkv1155; http://www.ncbi.nlm.nih.gov/pubmed/26527726; https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkv1155; https://dx.doi.org/10.1093/nar/gkv1155; https://academic.oup.com/nar/article/44/D1/D848/2502647
Oxford University Press (OUP)
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