Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients
Nephrology Dialysis Transplantation, ISSN: 0931-0509, Vol: 21, Issue: 12, Page: 3555-3558
2006
- 20Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef9
- Captures12
- Readers12
- 12
Article Description
Background. Thrombophilia has been implicated in the development of avascular necrosis (AVN) in various diseases. We aimed to search for the relation of both prothrombin gene G20210A mutation and factor V G1691A (factor V Leiden) mutation with AVN among kidney transplant recipients. Methods. Nineteen patients with AVN and 38 control patients without AVNwere included. Clinical information was collected, and gender, age, type of renal allograft, duration and type of dialysis, presence of acute rejection, and cumulative doses of ciclosporin and corticosteroid administration were taken into consideration. Genotypes of factor V G1691A and prothrombin G20210A were determined by direct sequencing of genomic DNA. Results. Factor V Leiden mutation was detected in six patients (31.6%) among patients with AVN and in only three patients (7.9%) in the control group (P = 0.048). Two patients (10.5%) in the AVN group were determined to have prothrombin G20210A mutation, while no prothrombin G20210A mutation was detected in the control group. When both of the mutations causing thrombophilia were considered, a total of eight patients (42.1%) in the AVN group and three patients (7.9%) in the control group were identified (P = 0.004). Conclusion. Thrombophilia seems to be an important risk factor for development of AVN. More studies are needed to clarify the role of factor V G1691A and prothrombin G20210A mutation for AVN. © Copyright 2006 Oxford University Press.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751419534&origin=inward; http://dx.doi.org/10.1093/ndt/gfl400; http://www.ncbi.nlm.nih.gov/pubmed/16968732; https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfl400; https://dx.doi.org/10.1093/ndt/gfl400; https://academic.oup.com/ndt/article-abstract/21/12/3555/1869174?redirectedFrom=fulltext
Oxford University Press (OUP)
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