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Starting subcutaneous insulin doses in a paediatric population with newly diagnosed type 1 diabetes

Paediatrics and Child Health, ISSN: 1205-7088, Vol: 15, Issue: 6, Page: 357-362
2010
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Metric Options:   Counts1 Year3 Year

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Article Description

BACKGROUND: Starting subcutaneous insulin doses in children with newly diagnosed type 1 diabetes vary widely from 0.2 units/kg/day to 0.8 units/kg/day. AIM: To determine whether there are correlations between starting insulin dose and diabetes-related outcomes. METHODS: By reviewing the charts of children newly diagnosed with type 1 diabetes, the prevalence of hypoglycemia in the first 48 h was compared between those who received low (0.5 units/kg/day or less) and those who received high (greater than 0.5 units/kg/day) starting insulin doses. RESULTS: Forty-two children were initially prescribed a low dose of insulin, and 55 children were given a high dose. Approximately onethird of children (36.4%) younger than six years of age who received a high starting dose of insulin had mild hypoglycemia within 48 h of subcutaneous insulin initiation, compared with 16.0% of children six to 10 years of age and 5.3% of children older than 10 years of age. CONCLUSIONS: Hypoglycemia was not more frequent among children given high-insulin starting doses. However, children younger than six years of age remained at increased risk for hypoglycemia. ©2010 Pulsus Group Inc. All rights reserved.

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