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Hydrogen peroxide detection with high specificity in living cells and inflamed tissues

Regenerative Biomaterials, ISSN: 2056-3426, Vol: 3, Issue: 4, Page: 217-222
2016
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Article Description

Hydrogen peroxide (HO) detection in biological systems is of significant importance, which act as critical second messenger in fundamental biological processes. Here, we report on a chemoselective fluorescent naphthylimide peroxide probe (NPP) for the HO detection in vitro and in vivo. NPP is a phenylboronic acid-caged chromophore that selectively responds to HO through a selfimmolate mechanism. NPP exhibited high sensitivity and selectivity to HO with distinctive fluorescence change due to the excellent two-photon excitation property, which permits the facile detection of inflammation produced HO and offers chance to monitor the inflammatory stages in diseased cells.

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