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Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation

Schizophrenia bulletin, ISSN: 1745-1701, Vol: 41, Issue: 1, Page: 44-56
2015
  • 60
    Citations
  • 0
    Usage
  • 131
    Captures
  • 1
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    60
  • Captures
    131
  • Mentions
    1
    • References
      1
      • Wikipedia
        1
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

Review Description

Cognitive deficits are commonly observed in patients with schizophrenia. Converging lines of evidence suggest that these deficits are associated with impaired long-term potentiation (LTP). In our systematic review, this hypothesis is evaluated using neuroimaging literature focused on proton magnetic resonance spectroscopy, positron emission tomography, and single-photon emission computed tomography. The review provides evidence for abnormal dopaminergic, GABAergic, and glutamatergic neurotransmission in antipsychotic-naive/free patients with schizophrenia compared with healthy controls. The review concludes with a model illustrating how these abnormalities could lead to impaired LTP in patients with schizophrenia and consequently cognitive deficits.

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