Osteocyte biology
Current Opinion in Orthopaedics, ISSN: 1041-9918, Vol: 14, Issue: 5, Page: 311-316
2003
- 4Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Review Description
Purpose of review: The study of osteocytes has lagged behind the study of osteoclasts and osteoblasts, for which there exists reams of literature. However, significant advances have been made recently in the area of osteocyte biology. The purpose of this review is to assimilate new information regarding osteocytes from the most recent publications limited to April 1, 2002 through March 31, 2003. Recent findings: Recent findings include markers for osteocytes that might lend insight into their function. Transforming growth factor-β appears to be playing a role in the differentiation process of the osteoblast to the osteocyte. More questions than answers are raised concerning the relation of osteocyte density to parameters such as bone volume and bone remodeling. In addition to data on the effects of mechanical forces on osteocytes, information on the effects of biophysical forces such as pulsed electromagnetic fields and ultrasound are being investigated. The hypothesis that osteocytes can direct both osteoclastic bone resorption and osteoblastic bone formation is being validated. Whether the cell supports resorption or formation may depend on the viability state of the cell. These studies on osteocyte viability and the osteocytic response to mechanical and biophysical forces have implications for clinical research and practice. For example, reduced mechanical forces on the skeleton, in conjunction with changes in systemic hormones, could contribute to bone loss resulting from disease such as osteoporosis. Osteocyte cell death or apoptosis may also be responsible for bone loss. Summary: Currently, mechanical strain is still necessary for the efficacy of bone-inducing agents such as parathyroid hormone or bone-maintaining agents such as estrogen. It is predicted that the osteocyte will become a target for therapeutic intervention. © 2003 Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0041335478&origin=inward; http://dx.doi.org/10.1097/00001433-200310000-00002; http://journals.lww.com/00001433-200310000-00002; https://journals.lww.com/00001433-200310000-00002; https://dx.doi.org/10.1097/00001433-200310000-00002; https://journals.lww.com/co-ortho/Abstract/2003/10000/Osteocyte_biology.2.aspx
Ovid Technologies (Wolters Kluwer Health)
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