PlumX Metrics
Embed PlumX Metrics

Octopamine modulates ionic currents and spiking in dorsal unpaired median (DUM) neurons

NeuroReport, ISSN: 0959-4965, Vol: 8, Issue: 17, Page: 3737-3741
1997
  • 31
    Citations
  • 0
    Usage
  • 17
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

MODULATORY effects of octopamine on ionic currents and spiking in isolated cockroach dorsal unpaired median neurons were investigated by means of the chopped voltage-/current-clamp and the patch-clamp technique. Octopamine increased the spiking frequency at concentrations ≤ 10 μM and reduced it at > 10 μM. It enhanced a low voltage-activated Ca current at 1 to 100 μM. At concentrations up to 10 μM two components of Ca- activated K current were potentiated. At > 10 μM octopamine in addition reduced a high voltage-activated Ca current and the Ca-activated K current. A membrane permeant cAMP-analogue imitated the effects obtained at high octopamine concentration. Octopamine and cAMP in addition reduced a depolarizing resting current at both low and high concentration. Possible mechanisms and physiological significance are discussed for the opposite effects of octopamine observed at low versus high concentrations.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know