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Time-dependent reversal of dentate LTP by 5 Hz stimulation

NeuroReport, ISSN: 0959-4965, Vol: 9, Issue: 17, Page: 3775-3781
1998
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Article Description

Field potential recordings were made from the dentate gyrus of urethane- anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTP in vivo exhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA1 in vitro.

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