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Modulation of intracellular Na concentration by BmK AS, a scorpion toxin, in B104 cell line

NeuroReport, ISSN: 0959-4965, Vol: 15, Issue: 1, Page: 13-16
2004
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ABSL Effects of BmK AS, a toxin from scorpion Buthus martensi Karsch and an activator of skeletal muscle RyRs, on the intracellular Na concentration have been investigated in the B104 neuroblastoma cell line by fluorescence digital imaging techniques. The intracellular Na concentration was elevated by 500 nM BmK AS significantly over a 30 min period, and the effect could be enhanced by addition of ouabain. In addition, BmK AS induced a biphasic modulation of [Na] in the dose-dependent range from 20 to 500 nM in the presence of ouabain. The results suggest that BmK AS may modulate intracellular signals by altering the intracellular Na concentration in the B104 cells. © 2004 Lippincott Williams & Wilkins.

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