Is the persistent sodium current a specific target of anti-absence drugs?
NeuroReport, ISSN: 0959-4965, Vol: 15, Issue: 6, Page: 1049-1052
2004
- 28Citations
- 23Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations28
- Citation Indexes28
- 28
- CrossRef19
- Captures23
- Readers23
- 23
Article Description
The persistent Na current (I) has been proposed as the putative target of the anti-absence antiepileptic drugs. Accordingly, the effect of reference anti-absence drugs ethosuximide (ESM) and valproate (VPA), and of the new antiepileptic drug levetiracetam (LEV), on I have been tested in CAI hippocampal neurons and compared to the classic anticonvulsant phenytoin (PHT) and the neuroprotective agent riluzole (RIL). Whole-cell patch-clamp recordings of the slowly inactivating current, fully characterized as I, were performed with a standard voltage-step protocol on thin hippocampal slices prepared from rat brain. Both PHT (100 μM) and RIL (10 μM) strongly depressed I, whereas ESM (1 mM) induced a slight decrease of I and VPA (1 mM) had no effect. Likewise, 60-min perfusion with relevant concentrations of LEV (10, 32 or 100 μM) did not modify I. In conclusion, these data question the impact of I depression as an anti-absence mechanz ism, and also discalim the involvement of I in the antiepileptic mechanism of LEV. © 2004 Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=2342573680&origin=inward; http://dx.doi.org/10.1097/00001756-200404290-00023; http://www.ncbi.nlm.nih.gov/pubmed/15076732; http://journals.lww.com/00001756-200404290-00023; https://dx.doi.org/10.1097/00001756-200404290-00023; https://insights.ovid.com/article/00001756-200404290-00023
Ovid Technologies (Wolters Kluwer Health)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know