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Assessment of QTc prolongation following thioridazine withdrawal in a developmentally disabled population [2]

Journal of Clinical Psychopharmacology, ISSN: 0271-0749, Vol: 23, Issue: 3, Page: 314-315
2003
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Indications:15 patients with coexisting developmental disability. Patients:15 patients (12 males, 3 females; aged 42.7 years, range 27-57 years). Follow-up: 8 weeks postdiscontinuation; 2 patients followed every 6 months thereafter. TypeofStudy:QTc interval prolongation associated with Melleril withdrawal in developmentally disable patients was assessed. DosageDuration:Dosage and duration not stated. Results:Even with the increased QTc prolongation interval, 2 persons' intervals remained less than 400 msec. Another individual was on the cutoff, and the interval increased only slightly. The remaining 2 individuals experienced more marked increases (408 vs. 448 and 401 vs. 456 msec). AdverseEffects:5 patients experienced increases in QTc interval prolongation times after discontinuation. FreeText:Tests done: electrocardiogram monitoring.

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