Reappraisal of biochemical hepatitis C activity in hemodialysis patients
Journal of Clinical Gastroenterology, ISSN: 0192-0790, Vol: 30, Issue: 2, Page: 187-194
2000
- 23Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations23
- Citation Indexes22
- 22
- CrossRef16
- Clinical Citations1
- PubMed Guidelines1
- Captures24
- Readers24
- 24
Article Description
We reappraised biochemical hepatitis C activity in hemodialysis patients in comparison with normal controls. A total of 111 hemodialysis patients and 66 healthy volunteer blood donors with hepatitis C virus (HCV) infection were consecutively enrolled. Serum alanine aminotransferase (ALT) levels were normal (≤45 U/L) in 103 (93%) hemodialysis patients and 34 (52%) donors (p < 0.001). HCV viremic levels were lower in the hemodialysis group (p = 0.044), with no difference in the HCV genotype prevalence. During two-year follow-up, 60 (67%) of 90 hemodialysis patients and 13 (26%) of 50 donors showed persistently normal ALT levels (p < 0.001). For hemodialysis patients, however, the upper normal limit of ALT activity was reset at 25 U/L corresponding to the mean + 2 x SD for the normalized ALT distribution in 400 control patients. The adjusted ALT levels were initially normal in 73 (66%) hemodialysis patients and persistently normal in 19 (21%). Thus, ALT levels were the same for the two groups. GB virus C (GBV-C)/hepatitis G virus (HGV) coinfection found only in the hemodialysis group (10/111) had no influence on the disease. A relationship was noted between low disease activity and female gender in both groups. These findings indicate that biochemical hepatitis C activity in hemodialysis patients is similar to that in normal controls and should be monitored based on adjusted ALT levels.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034018006&origin=inward; http://dx.doi.org/10.1097/00004836-200003000-00012; http://www.ncbi.nlm.nih.gov/pubmed/10730925; http://journals.lww.com/00004836-200003000-00012; https://dx.doi.org/10.1097/00004836-200003000-00012; https://journals.lww.com/jcge/Abstract/2000/03000/Reappraisal_of_Biochemical_Hepatitis_C_Activity_in.12.aspx
Ovid Technologies (Wolters Kluwer Health)
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